For a full comparison of weight loss peptides beyond GLP-1 medications, see our best peptides for weight loss guide
Historically, sermorelin acetate was marketed as Geref and used as a diagnostic and therapeutic agent for growth hormone deficiency, particularly in children, before being withdrawn from several markets for commercial reasons rather than safety concerns
Based on available Phase 2 data, both agents share a side-effect profile broadly consistent with other medicines acting on metabolic hormone pathways, though the triple-agonist mechanism of retatrutide introduces some additional considerations
Your dose may need to go up over time as your body adjusts, but your monthly price remains flat
Tirzepatideis the first drug in a class of agents known as dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) receptor agonists
Zhao P, Liang YL, Belousoff MJ, et al