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273 Astrocytes infected with the virus demonstrated signs of reactivity, increased cytokine production and cellular stress

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An example of such can be observed in a study where Cre-dependent activation of Ube3a in Ube3a Stop/p+ embryonic mice restored all AS-associated motor, behavioral, and neurological deficits, whereas Ube3a reactivation in postnatal mice demonstrated diminishing efficacy with age for motor coordination rescue [183]