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However, activation of GIP-1R by TZT in T2DM patients improves glucose homeostasis

*In the STEP 1 trial, participants received semaglutide 2.4 mg once weekly via subcutaneous injection, the FDA-approved formulation later marketed under the brand name Wegovy for chronic weight management in adults with obesity or overweight and at least one weight-related condition

PlexusDx's Precision Peptide Genetic Test examines these variants and can support more nuanced conversations with your provider about whether a particular GLP-1 formulation, starting dose, or titration schedule aligns with your genetic profile

The closest randomized human safety data is for the synthetic analog CB4211, not for native MOTS-c

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