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Targeting PI3K/mTOR pathways has shown promise in preclinical trials, with omipalisib being well-tolerated in IPF subjects [148, 149]

Ferroptosis is a type of regulated cell death caused by iron overload and lipid peroxidation, which is distinct from pyroptosis, necrosis, and apoptosis

Furthermore, it actively shifts the body's melanin production away from eumelanin (dark brown/black pigments) toward pheomelanin (lighter pigments)

doi: 10.1007/s00125-006-0481-3 27 KazdaCMDingYKellyRPGarhyanPShiCLimCNet al

Store below 25 C and protect from light

9 Research gaps and future priorities 9.1 Reproductive-oriented RCTs: shifting from metabolic surrogates to hard endpoints To date, most GLP-1RA trials in PCOS have been designed around metabolic efficacy (weight change and insulin-resistance/glycaemic indices) as the primary outcomes, with reproductive outcomesovulation, clinical pregnancy, and live birthreported inconsistently and often as secondary or exploratory measures