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JAMA 327(2):138150 Bergmann NC et al (2023) Semaglutide for the treatment of overweight and obesity: a review

It represents a significant advancement, offering a pathway to health improvements beyond just aesthetic changes

Both compounds represent formidable tools in the ongoing quest to understand and modulate human metabolism

Insurance coverage is inconsistent depending on the plan and medication type

But the negative effects of metformin on exercise-induced benefits raise concerns about the use of metformin for anything other than for approved diseases such as T2DM

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