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This chronic state of severe oxidative stress damages cellular membranes through a destructive process known as lipid peroxidation, creating a highly toxic internal cellular environment

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A defining feature is the dual role of autophagy, which can either suppress or induce ferroptosis depending on the genetic background, LC subtype and microenvironmental cues

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(2000) Identification of the gene encoding sulfopyruvate decarboxylase, an enzyme involved in biosynthesis of coenzyme M