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As seen previously with liraglutide, the most frequently reported side effects were gastrointestinal, but dose-escalation helps to mitigate these

The dual agonist action on both GIP and GLP-1 receptors may produce different gastrointestinal effects compared to single GLP-1 agonists, though comparative data specifically regarding reflux incidence remain limited

Developed by Eli Lilly, retatrutide simultaneously targets GLP-1, GIP, and glucagon receptors, setting it apart from existing licensed treatments such as semaglutide and tirzepatide

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