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Testosterone Replacement Therapy (TRT) delivers clear benefits: improved libido, mood, muscle mass, and energy

Brain fog lifted

Dopamine supplementation would be evident, but this hydrophilic neurotransmitter does not cross the BBB and cannot enter the CNS due to brain endothelial tight junctions, active brain endothelial metabolism and lack of transporters [5]

Slower Adjustment to Appetite and Digestive Changes Some patients describe a preference for gradual changes rather than rapid shifts in hunger or digestion

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Clinical trials at doses up to 40mg daily for 12 weeks have reported no serious adverse effects (Brendler & Williamson, 2019, Phytomedicine )