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MOTS-c is classified as a mitochondrial-encoded peptide and is commonly explored in studies examining cellular metabolism, stress-response signaling, and mitochondrial communication mechanisms

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8 Under diabetic conditions (eg, hyperglycemia and dyslipidemia), neural structure is disrupted, accompanied by bioenergetic deficits, impaired insulin signaling, inflammation, oxidative stress, microvascular damage (Figure 1b)

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Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC