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Figure 5: A) Time spent below range, time in range, time above high range, and time in tight range
Why pulsatile and endogenous matters Because these analogs stimulate the pituitary rather than replacing GH, the resulting secretion tends to preserve the bodys natural pulsatile rhythm and remains subject to normal feedback control somatostatin, IGF-1 negative feedback, and the finite secretory capacity of the gland
Viennois and colleagues (Cell Mol Gastroenterol Hepatol, 2016, PMID 27458604) reported that the effect was lost in PepT1-knockout mice, making the transporter the gating step
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Sakurai, H., Miyoshi, H., Toriumi, W