La participacin de la prdida de peso en los efectos del tratamiento con LIRA en el programa SCALE es variable, encontrndose en torno al 100% en resultados sobre fracciones lipdicas, presin arterial e ndice apnea-hipopnea y alrededor del 30% en los efectos sobre el metabolismo hidrocarbonado, en probable relacin con el efecto incretnico del frmaco20
But those numbers undercount the reality, because many people do not report burping as a side effect
The effect can be prolonged by lower gut bacterial action on fermentable fibers (see below) to produce short-chain fatty acids (propionate, butyrate, etc.) Healthful naturally-occurring animal fats such as tallow, lard, butter, and schmalz, the oils of fatty fish (salmon, mackerel, sardines, trout) and fruit and nut oils (coconut oil, olive oil, avocado oil, macadamia nut oil) activate free fatty acid receptors on Lcells to stimulate the release of GLP-1 from the gut and prolong its activity.There was early research that seemed to indict a diet high in saturated fats (what a surprise) as potentially toxic to the L-cells over time, but all that research was done in isolated cell models or high-fat/high carb rodent diets, not in a ketogenic diet context in humans
Stepien, Brian A
doi: 10.1002/14651858.CD011669.pub2
Cycle 8-12 weeks on, followed by 4 weeks off
