Ci aumenta la concentrazione di malonil-CoA, il primo intermedio nella sintesi degli acidi grassi, portando all'inibizione della carnitina aciltransferasi 1, impedendo cos l'ingresso di acidi grassi nella matrice mitocondriale per la ossidazione
What makes this especially intriguing is that GLP1 effects may extend to other hedonic drives, such as highcalorie eating, hinting at shared neural circuitry
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doi: 10.1038/mt.2008.115
Novel SIM1 variants expanding the spectrum of SIM1-related obesity
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