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This enzyme is tryptophan 2,3-dioxygenase which is encoded by the TDO2 gene

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The CTH@MN system (CeO 2 @Tau@Hydrogel@Microneedle), leveraging taurines anti-senescence properties and cerium oxides mtROS-scavenging ability, successfully inhibited the ROS/NF-B pathway and activated autophagy in diabetic wounds, attenuating oxidative damage and inflammation while countering cellular senescence to create a pro-regenerative immune microenvironment (Tian et al., 2024

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