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Those engaging in physical activity, living in hot climates, or experiencing increased urination (common with hyperglycemia or SGLT2 inhibitor medications) require additional hydration beyond baseline recommendations
PMID 25493285
Some appetite suppression may occur but weight loss is minimal
Compounded oral drops require careful pharmacy and provider oversight
Clinical trials of Foundayo (orforglipron) reported average A1C reductions ranging from about 1.2% to 1.7% depending on the dose, with many participants reaching target A1C levels below 7%
Some patients find that consuming a small protein-rich snack before their weekly injection helps minimise subsequent side effects, though this is based on personal experience rather than clinical evidence
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