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Reductions in this ratio correlate strongly with cardiovascular risk reduction and metabolic improvement

That is a real finding, but it describes group averages, not individuals

EVIDENCE GRADES SCALE-Obesity (Pi-Sunyer 2015, PMID 26132939) reported 8.0% body-weight loss at liraglutide 3.0 mg vs 2.6% placebo at 56 weeks

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In particular, it is important to rule out a physical/structural blockage of the intestines, including malrotation, with an upper gastrointestinal series of radiographs

results often require several months of consistent therapy