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No mice receiving indomethacin and esomeprazole died, but the death rate while receiving indomethacin was 38% ( 2 , P = 0.05)

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Second, it is able to induce the combination of ,-unsaturated ketones and GSH through the nucleophilic addition reaction, depleting GSH and reducing the amount of GSH available to combine with chemotherapeutic agents, thus producing an overall GST-inhibitory effect by sensitizing a cell to chemotherapeutic agents