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The 2026 Sports Medicine and JAAOS Global Research and Reviews papers (PMID 41966639, PMID 41490200) place multiple compounds including this one into the wider research context of unapproved compounds under active investigation, with attention to both the mechanism findings and the regulatory framing that researchers consulting these reviews should weigh equally

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It means the agency did not have reliable human data showing what exposure they produce, whether they help, how often adverse effects occur, or how product variability affects results

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