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Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder in which spinal and cortical motor neurons progressively degenerate

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In animal studies, DSIP demonstrated anxiolytic effects, reducing anxiety-like behavior in mice (Shekunova et al., 2002), and lowering plasma corticosterone levels in rats (Kovalzon et al., 1997)

Some people also experience reduced appetite, fatigue, or mild headaches during the adjustment period

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No heterogeneity was presented in the included studies (I 2 = 0%, P = 0.39), and we used the fixed effects model (Fig