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Why Some Patients Feel Fatigued on GLP-1 Therapy Fatigue during the first weeks of GLP-1 treatment can stem from several sources: rapid calorie reduction, electrolyte shifts, dehydration, or inadequate protein intake

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Real-World Data In a registry of 1,200 adults with type 2 diabetes and obesity, 65% reported 2% body weight reduction at six months, and 30% lost 5%

Intermittent use is generally safe under supervision