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In a 56-week clinical trial , people who took liraglutide lost an average of 6.4 kg (14 pounds) with the 3 mg dose and 5 kg (11 pounds) with the 1.8 mg dose, compared to 2.2 kg (5 pounds) with placebo, with higher doses leading to greater weight loss

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This distinction matters because biosimilars may not always receive automatic substitution status at the pharmacy level