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Notably, specific gut microbiota-derived metabolites, such as indolepropionic acid and trimethylamine-N-oxide, correlate strongly with the severity of renal fibrosis, suggesting their potential as clinically relevant biomarkers for the early detection and therapeutic monitoring of DN management (17)

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The most significant interaction involves other glucose-lowering drugs

a , Schematic of Glp1r-Cre mice injected with a Cre-dependent AAV carrying full-length mouse Glp1r (mGlp1r) or AAV carrying full-length mouse GLP1R with the S33W mutation at position 33 (mGLP1R S33W ) in the CeA