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XY: Validation, Writing review & editing

The effect on astrocytes may happen independently of Nrf2, since cofilin-1, tubulin and collapsin response mediator protein 2 (CRMP2) activity was seen to be mediated by DMF and reduced cytoskeletal remodeling (173)

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3.6.2 Gutbrain axis alterations in stroke Growing evidence reveals that stroke not only disrupts CNS homeostasis but also profoundly alters the MGBA, leading to bidirectional interactions that can exacerbate neuroinflammation and hinder recovery

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However, for concentrations exceeding three g/dl, dilution with a 0.1 M phosphate buffer at pH 7.0 was necessary to obtain reliable results