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A patient may need a different dosage form, a strength that is not commercially available, or a formulation that omits an ingredient to which the patient is allergic

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These characteristics originally made it an important subject in gastrointestinal research before its investigation expanded into connective tissue and regenerative biology

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Prior to the main acute oral toxicity study, a pilot sighting study was conductedi.e., the limit test (OECD, 2002b)