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The other six patients gradually increased their dose, from 400 mg twice daily to 800 mg twice daily, over a one-month period

This could result in variability in dose, undeclared ingredients and potential microbial contamination

Over time, carriers have shifted from a single broad formulary to more personalized formularies by drug type, tightening criteria and improving cost management

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In chronic pancreatitis, the pancreas is now scarred - it may be atrophic (shriveled), or even calcified

Therefore, a full evaluation from a qualified healthcare professional, especially a colorectal surgeon, is the best and first course of action