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L-Proline is involved in the production of collagen, which is a structural protein present in connective tissue, tendons, joints, bones and vasculature (veins and arteries)

Chen et al., 2024)

Human data on piperlongumine are missing, apart from a single clinical study in Japanese women which showed that Piper longum extract increased peripheral blood flow and skin temperature after cold stress [99]

Their efficacy is significantly enhanced when complemented by healthy lifestyle choices, particularly dietary adjustments and regular physical activity

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