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10.1371/journal.pmed.1000097 37 NIHR (2025)

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The presence of the specialized tripeptide KPV allows researchers to monitor the competitive downregulation of nuclear factor kappa B (NF-kB) and trace the inhibition of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) within inflamed intestinal or cutaneous tissues

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Smoking also increases risk by reducing blood flow to spinal structures and impairing tissue repair