Nature 453 , 481488 (2008)
FIGURE 5 3.7 Bone diseases Osteoblast is the main functional cell leading bone formation in bone metabolism, which is very important for bone growth and bone balance maintenance
Assuming a sequential reaction, where the enzyme, GPX, must bind to both substrates, ROS and GSH, for the reaction producing GSSG to occur and letting ROS and GSH to be the leading and following substrates, respectively, is the the reaction rate for GSSG
When left unchecked, free radicals can cause oxidative damage to our cells, DNA, proteins, and lipids
On the other hand, in a study with 128 Parkinson's Disease patients, 40 and 80 mg MitoQ per day was associated with dose-dependent increased incidence of nausea and vomiting (Snow et al., 2010)
Potential side effects are usually associated with higher doses and may include mild digestive issues, especially when starting supplementation