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Importantly, women appear to respond well at lower injectable doses, and the most common approach combines topical and injectable use simultaneously for maximum cosmetic effect

In an observational study including 147 subjects were administered single-daily dose of various DPP-4 inhibitors like alogliptin (12.5 or 25 mg), teneligliptin (10 or 20 mg), and sitagliptin (25 or 50 mg) for 3 months

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Following contact, resulting in rapid hydrolysis, glucose is liberated and unstable aglycones are formed that spontaneously rearrange to metabolites such as the isothiocyanate, sulforaphane (Figure 2)