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Sermorelin binds directly to GHRH receptors, while Ipamorelin acts as a selective agonist at the ghrelin receptor (GHS-R1a)

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This receptor is activated by a variety of stimuli, including neuropeptides, antimicrobial peptides, immune mediators, and certain drugs

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This happens more often in the thigh than the abdomen because the thigh has a denser vascular network in some areas

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