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Acetylation is responsible for the metabolism of caffeine, histamine, aromatic amines from industry, and many medications including benzodiazepines (sedative), isoniazid (antibiotic), hydralazine (vasodilator for hypertension) and sulphonamides (antibiotics)

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You can increase the dose as far as about 1mg but any higher is generally not advised and the users dosing 1mg/dose normally weigh around the 100kg mark

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