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How Your Genetics Relate to GLP-1 Pathways Four key genetic variants significantly influence how your body responds to GLP-1 therapy: the GLP1R rs6923761 polymorphism affects receptor density and signaling efficiency, GIPR rs1800437 impacts glucose-dependent insulinotropic peptide pathways, MC4R rs17782313 controls downstream melanocortin appetite signaling, and FTO rs9939609 influences metabolic rate and weight regulation

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