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PRISMA-P 2015 statement

The GLP-1 Legacy is a book that focuses specifically on this phase, with a foreword by Professor Jane Ogden

While mild, transient burning is generally benign, certain signs and symptoms warrant prompt medical evaluation

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Genetic and Metabolic Factors Influencing GLP-1 Response and Weight Trajectory Individual variation in GLP-1 receptor sensitivity, appetite hormone baseline levels, and metabolic flexibility significantly affect how your body responds to therapy and maintains weight loss

A phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023 demonstrated substantial weight loss in adults with obesity, and phase 3 trials are currently ongoing (see ClinicalTrials