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Louis show in a new study that GLP-1 medications may be effective at treating and preventing substance use disorders across all major addictive substances studied, suggesting these drugs target a common biological pathway underlying addiction

Then there is the glucagon receptor, which is unique to retatrutide among the current generation of weight loss peptides

Key takeaways: GLP-1 is a rapid-acting gut hormone that regulates blood sugar and appetite by signaling insulin release and suppressing glucagon

It is that they appear to modulate the same broad systems of reinforcement and craving that are central to addiction generally

Blood glucose experiment in db/db mice After the acclimation period (at least 5 days), mice (male db/db mice (Charles River laboratories) 7 weeks old, 40 g) were fasted for 6 h, then blood was collected to measure levels of glucose and insulin