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Clinical data show that weight regain is common after GLP-1 medications are discontinued, including a STEP 1 trial extension where participants regained about two-thirds of prior weight loss one year after stopping semaglutide and lifestyle intervention

In contrast, Amarasate mimics the natural cycle of GLP-1 production, but at twice the levels that normally occur in response to food intake

Rather than traveling across the city for routine appointments, many patients appreciate the flexibility of secure telehealth consultations that can often be completed from home

BMI 30 or higher : Eligible based on weight alone

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First, the human RCT footprint is thinner than the mechanism literature