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The most common adverse events included nausea, affecting 38.1% to 43.2% of treated patients compared to 10.7% with placebo, diarrhea in 33.1% to 34.7% versus 13.4% with placebo, and constipation in 21.8% to 25% compared to 8.7% with placebo

Well, the answer can be a bit more complex than that

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Wang ZH, Fu BQ, Lin YW, Wei XB, Geng H, Guo WX, et al