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Patients without diabetes seeking maximum weight loss typically do best on tirzepatide

Common problems include stomach pain, low blood sugar, and, less often, acute pancreatitis

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Among participants on tirzepatide, the rate of new-onset type 2 diabetes was dramatically lower: 0.4% for the 15 mg group compared to 13.3% for placebo over three years

[5] [11] Clinical trials have demonstrated significant weight loss with these medicationstypically 15% with semaglutide 2.4mg (Wegovy) and 5-8% with liraglutide 3.0mg (Saxenda) over 68 weekswhen used alongside dietary changes and physical activity advice