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Many patients use semaglutide or tirzepatide for 12 to 24 months to reach a goal weight, then transition to a lower maintenance dose or a structured taper while keeping lifestyle gains in place

Kennis found in several studies that a significant proportion of users stop treatment early, often because of side effects or disappointing results

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Then, an individual can start to treat any potential underlying reasons for the issue, such as dysbiosis or methylation issues