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Second, two authors (W.W., H.-M.T.) independently screened from each paper and extracted detailed data using standardized forms

(4) ongoing telehealth follow-up for dose titration and side-effect management

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(2018) Kleinman and Sosne (2016) Philp et al

Gather documentation: BMI measurement, relevant comorbidities, and evidence of a lifestyle program

Besides the well-known targets such as the inhibition of the mTOR signaling pathway, several additional metformin and phenformin targets (e.g., mGPDH, ATF3, STAT3, GSK3, cyclins) have been identified in other cancers (Thakur et al., 2019)