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These pathways play a crucial role in its wide-ranging therapeutic effects, extending the benefits of GLP-1RAs beyond metabolic diseases
IshibashiYMatsuiTOjimaANishinoYNakashimaSMaedaSet al
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The addition of GIP agonism changes the pharmacodynamic profile in ways that make simple dose conversion impossible
Apart from lifestyle modifications to reduce obesity through healthy diet and encouragement of physical activity, current pharmacologic therapeutic approaches are based upon increasing insulin availability (either through direct insulin administration or through agents that promote insulin secretion), improving sensitivity to insulin, delaying the delivery and absorption of carbohydrate from the gastrointestinal tract, or increasing urinary glucose excretion [8]
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