The buffering genetic interaction revealed from our CRISPR screen 13 allowed further extending the finding by demonstrating a functional coordination of mitochondrial glutathione uptake (mediated by SLC25A39) and mitochondrial iron import (mediated by SLC25A37) in supporting OXPHOS
Ferroptosis in diabetes Since iron plays a key role in metabolic disease processes (such as glucose oxidation) and metabolic regulation (such as hypoxia sensing), it is involved in determining key energy metabolic links such as metabolic rate, gluconeogenesis, fuel selection, and insulin action
rNET, reverse norepinephrine transport
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Scientific understanding continues to develop as further controlled laboratory and preclinical data becomes available
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