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Studies have shown that the NLRP3 inflammasome is also involved in other skin diseases, such as psoriasis, urticaria, and bullous pemphigoid (179)

Adenosine: Reduces wrinkles and fine lines, promotes skin elasticity

Upon activation, NF-B translocates to the nucleus, where it induces the expression of pro-inflammatory and pro-ferroptotic genes, promote iron accumulation and reactive ROS production, leading to lipid peroxidation and ferroptosis (Min et al., 2025)

Age-related NAD+ decline

BSO treatment showed increased expression of Dnmt3a and 3b and decreased Tet2 and 3 transcripts, and it was not wholly restored after treatment withdrawal at different time points, as was shown by real-time PCR analyses (Fig

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