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in Frontiers in Pharmacology (2019) investigated the use of high-dose B12 nasal drops in 51 ME/CFS patients over 3 months

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Failure of energy transfer between identical aromatic molecules on excitation at the long wave edge of the absorption spectrum

Copper from the GHK-Cu component is also discussed as a reason for breaks, but no KLOW study has established a proven copper-clearance period