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In addition, HFD induces dysbiosis, reducing lactobacillus, which produces lactate

reported post-VSG increases in lumbar BMAT alongside peripheral MAT reductions, underscoring region-specific fatbone interactions, although other studies report a reduction in BMAT with VSG

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Modern GLP-1 receptor agonists have demonstrated average weight loss of 15-20% of body weight with sustained treatment, representing a breakthrough in obesity pharmacotherapy that approaches the effectiveness of bariatric surgery