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15 Consistent with their role in lipolysis, Bordicchia et al further demonstrated that ANP/BNP could activate the thermogenic program and mitochondrial biogenesis in human brown adipocytes, a process mediated by p38 MAPK signalling pathways

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Determining if patients actually took their medication or capturing adjustments to dosing outside of the prescription (for example, physicians gradually up-titrating patients doses) was not possible