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Joseph Volpicelli, a psychiatrist and addiction-medication researcher in Pennsylvania, the drug can also affect the brain's reward circuit, dulling the dopamine hit someone might otherwise get from a greasy french fry or dirty martini

doi: 10.1126/science.1071884 171 StraubRH

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Available at: [Accessed 27th August 2020]

Visible changes often show before dramatic weight drops