This work was supported in part by Zhejiang Provincial Natural Science Foundation of China (LRG25C060001), National Natural Science Foundation of China (32541027, 32570646, 32370591, 32271343, 32070632 an 92053114), National Key R&D Program of China (2022YFA1303000), Fundamental Research Funds for the Central Universities (226-2025-00028), Innovative Research Team of High-level Local University in Shanghai (to J.H.) and Medical Science Data Center of Fudan University
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