At hormonal levels, Copper Tripeptide-1 acts as a chemoattractant for fibroblasts (repairing cells) and activates a plethora of regenerative processes in the skin, such as angiogenesis, production of extracellular matrix components, including collagen, elastin, proteoglycans, glycosaminoglycans, etc, additionally activating metalloproteinases (MMPs) involved in tissue remodeling
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Therefore, chronic activation of the NLRP3 inflammasome promotes fibroblast differentiation into MYFs, which results in excessive collagen deposition and tissue scarring, contributing to chronic inflammation and fibrosis [169, 170]
