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Orskov C, Wettergren A, and Holst JJ

Fasting insulin, C-peptide, and HOMA2-IR fell by as much as 50 percent or more

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In humans, rimonabant was equally effective as judged by initial clinical studies [426][427][428][429][430] , but due to concern over its depressive side effects, the drug was not approved for use in the United States and after initial approval in Europe was removed from the market