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The predicted differences between the lead compounds and CQ in P-glycoprotein modulation, and CYP2D6 and CYP3A metabolism suggests that the lead compounds present favorable and less metabolism-based drug interactions

Meanwhile, PCNA and Cyclin D1Western blot data indicated that mice lack of 5-HT experienced a lower level of liver regeneration after the APAP overdose and exhibited significantly lower cell proliferation at 72 hours after APAP administration

10.3233/bir-1987-24611 101 KleinA.LamblinG.LhermitteM.RousselP.BregJ.Van HalbeekH.et al (1988)

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