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[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Kstle M., Grimm S., Nagel R., Breusing N., Grune T

Research into these mechanisms is still evolving, and microdose-level effects have not been specifically studied in clinical trials, but the biological rationale is sound: activating two complementary hormonal pathways at low levels may produce a broader metabolic nudge than activating one pathway alone

References and Resources Aronne LJ, et al

The trial established the IGF-1 axis as a clinical therapeutic target and supports the broader pharmacological rationale for IGF-1 receptor agonism, of which IGF-1 LR3 is one analog with extended pharmacokinetic properties

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